Genome-wide discovery of selection signatures in four Anatolian sheep breeds revealed by ddRADseq.

ABSTRACT: High-density genomic data analyzed by accurate statistical methods are of potential to enlighten past breeding practices such as selection by unraveling fixed regions. In this study, four native Turkish sheep breeds (80 samples) were genotyped via 296.097 single nucleotide polymorphisms (SNPs) detected by double-digest restriction site-associated DNA (ddRADseq) library preparation combined with the Illumina HiSeq X Ten instrument in order to identify genes under selection pressure. A total of 32, 136, 133, and 119 protein-coding genes were detected under selection pressure by runs of homozygosity (ROH), integrated haplotype score (iHS), the ratio of extended haplotype homozygosity (Rsb), and fixation index (F_ST) approaches, respectively. Of these, a total of 129 genes were ident

SUBMITTER: Argun Karsli B 

PROVIDER: S-EPMC11371811 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature