Calculating Within-Pair Difference Scores in the Co-twin Control Design. Effects of Alternative Strategies.

ABSTRACT: Co-twin studies are an elegant and powerful design that allows controlling for the effect of confounding variables, including genetic and a range of environmental factors. There are several approaches to carry out this design. One of the methods commonly used, when contrasting continuous variables, is to calculate difference scores between members of a twin pair on two associated variables, in order to analyse the covariation of such differences. However, information regarding whether and how the different ways of estimating within-pair difference scores may impact the results is scant. This study aimed to compare the results obtained by different methods of data transformation when performing a co-twin study and test how the magnitude of the association changes using each of those approac

SUBMITTER: Madrid-Valero JJ 

PROVIDER: S-EPMC11371853 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature