Leveraging continuous glucose monitoring for personalized modeling of insulin-regulated glucose metabolism.

ABSTRACT: Continuous glucose monitoring (CGM) is a promising, minimally invasive alternative to plasma glucose measurements for calibrating physiology-based mathematical models of insulin-regulated glucose metabolism, reducing the reliance on in-clinic measurements. However, the use of CGM glucose, particularly in combination with insulin measurements, to develop personalized models of glucose regulation remains unexplored. Here, we simultaneously measured interstitial glucose concentrations using CGM as well as plasma glucose and insulin concentrations during an oral glucose tolerance test (OGTT) in individuals with overweight or obesity to calibrate personalized models of glucose-insulin dynamics. We compared the use of interstitial glucose with plasma glucose in model calibration, and evaluated t

SUBMITTER: Erdos B 

PROVIDER: S-EPMC11371931 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature