Predictive value of polygenic risk score for prostate cancer incidence and prognosis in the Han Chinese.

ABSTRACT: Although prostate cancer is a common occurrence among males, the relationship between existing risk prediction models remains unclear. The objective of this hospital-based retrospective study is to investigate the impact of polygenic risk scores (PRSs) on the incidence and prognosis of prostate cancer in the Han Chinese population. A total of 24,778 male participants including 903 patients with prostate cancer at Taichung Veterans General Hospital were enrolled in the study. PRS was calculated using 269 single nucleotide polymorphisms and their corresponding effect sizes from the polygenic score catalog. The association between PRS and the risk prostate cancer was evaluated using Cox proportional hazards regression model. Among the 24,778 participants, 903 were diagnosed with prostate canc

SUBMITTER: Hung SC 

PROVIDER: S-EPMC11372043 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature