Neutrophil extracellular traps mediate the crosstalk between plaque microenvironment and unstable carotid plaque formation.

ABSTRACT: The development of unstable carotid atherosclerotic plaques is associated with the induction of neutrophil extracellular traps (NETs) via the activation of diverse inflammatory mediators in the circulating bloodstream. However, the underlying mechanisms through which NETs influence the microenvironment of atherosclerotic plaques and contribute to the development of unstable carotid plaques remain largely elusive. The objective of this study was to elucidate the role of myeloid differentiation protein 1 (MD-1, LY86)-induced NETs underlying the crosstalk between unstable plaque formation and the plaque microenvironment. We employed bioinformatics analysis to identify key genes associated with carotid-unstable plaque, followed by comprehensive validation using various experimental approaches

SUBMITTER: Cao Y 

PROVIDER: S-EPMC11372095 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature