Sintilimab (anti-PD-1 antibody) combined with high-dose methotrexate, temozolomide, and rituximab (anti-CD20 antibody) in primary central nervous system lymphoma: a phase 2 study.

ABSTRACT: Primary central nervous system lymphoma (PCNSL) is a rare and frequently fatal lymphoma subtype. The programmed death-1 (PD-1) pathway has emerged as a potential therapeutic target, but the effectiveness of PD-1 antibody sintilimab in combination with immunochemotherapy as a frontline treatment for PCNSL remains to be determined. In this phase 2 trial (ChiCTR1900027433) with a safety run-in, we included patients aged 18-70 with newly diagnosed PCNSL. Participants underwent six 21-day cycles of a SMTR regimen, which includes sintilimab (200 mg, Day 0), rituximab (375 mg/m², Day 0), methotrexate (3.0 g/m², Day 1 or 1.0 g/m² for patients aged ≥65 years), and temozolomide (150 mg/m²/d, Days 1-5). Among 27 evaluable patients, the overall response rate

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC11372099 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature