Ultrasound and x-ray imageable poloxamer-based hydrogel for loco-regional therapy delivery in the liver.

ABSTRACT: Intratumoral injections have the potential for enhanced cancer treatment efficacy while reducing costs and systemic exposure. However, intratumoral drug injections can result in substantial off-target leakage and are invisible under standard imaging modalities like ultrasound (US) and x-ray. A thermosensitive poloxamer-based gel for drug delivery was developed that is visible using x-ray imaging (computed tomography (CT), cone beam CT, fluoroscopy), as well as using US by means of integrating perfluorobutane-filled microbubbles (MBs). MBs content was optimized using tissue mimicking phantoms and ex vivo bovine livers. Gel formulations less than 1% MBs provided gel depositions that were clearly identifiable on US and distinguishable from tissue background and with minimal acoustic artifacts

SUBMITTER: Delgado JF 

PROVIDER: S-EPMC11372101 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature