Increased coherence predicts medical refractoriness in patients with temporal lobe epilepsy on monotherapy.

ABSTRACT: Among patients with epilepsy, 30-40% experience recurrent seizures even after adequate antiseizure medications therapies, making them refractory. The early identification of refractory epilepsy is important to provide timely surgical treatment for these patients. In this study, we analyze interictal electroencephalography (EEG) data to predict drug refractoriness in patients with temporal lobe epilepsy (TLE) who were treated with monotherapy at the time of the first EEG acquisition. Various EEG features were extracted, including statistical measurements and interchannel coherence. Feature selection was performed to identify the optimal features, and classification was conducted using different classifiers. Functional connectivity and graph theory measurements were calculated to identify ch

SUBMITTER: Hwang S 

PROVIDER: S-EPMC11372158 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature