Altered lipid metabolism promoting cardiac fibrosis is mediated by CD34⁺ cell-derived FABP4⁺ fibroblasts.

ABSTRACT: Hyperlipidemia and hypertension might play a role in cardiac fibrosis, in which a heterogeneous population of fibroblasts seems important. However, it is unknown whether CD34⁺ progenitor cells are involved in the pathogenesis of heart fibrosis. This study aimed to explore the mechanism of CD34⁺ cell differentiation in cardiac fibrosis during hyperlipidemia. Through the analysis of transcriptomes from 50,870 single cells extracted from mouse hearts and 76,851 single cells from human hearts, we have effectively demonstrated the evolving cellular landscape throughout cardiac fibrosis. Disturbances in lipid metabolism can accelerate the development of fibrosis. Through the integration of bone marrow transplantation models and lineage tracing, our study showed that hyperli

SUBMITTER: Du L 

PROVIDER: S-EPMC11372182 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature