The therapeutic targets and signaling mechanisms of ondansetron in the treatment of critical illness in the ICU.

ABSTRACT: There is accumulating evidence regarding the benefits of the 5-HT3 receptor antagonist ondansetron for the treatment of critical illness due to its potential anti-inflammatory effect. This study attempted to determine the potential targets and molecular mechanisms of ondansetron's action against critical illnesses. A bioinformatics analysis of network pharmacology was conducted to demonstrate screening targets and the signaling pathways of ondansetron action against the most common critical illnesses such as acute kidney injury (AKI), sepsis, and acute respiratory distress syndrome (ARDS). Experiments of LPS-stimulated rat neutrophils with ondansetron treatment were conducted to further validate the relevant hypothesis. A total of 198, 111, and 26 primary causal targets were identified fro

SUBMITTER: Tao L 

PROVIDER: S-EPMC11372243 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature