Linking menopause-related factors, history of depression, APOE ε4, and proxies of biological aging in the UK biobank cohort.

ABSTRACT: In a subset of females, postmenopausal status has been linked to accelerated aging and neurological decline. A complex interplay between reproductive-related factors, mental disorders, and genetics may influence brain function and accelerate the rate of aging in the postmenopausal phase. Using multiple regressions corrected for age, in this preregistered study we investigated the associations between menopause-related factors (i.e., menopausal status, menopause type, age at menopause, and reproductive span) and proxies of cellular aging (leukocyte telomere length, LTL) and brain aging (white and gray matter brain age gap, BAG) in 13,780 females from the UK Biobank (age range 39-82). We then determined how these proxies of aging were associated with each other, and evaluated the effects of

SUBMITTER: Crestol A 

PROVIDER: S-EPMC11372440 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature