Autonomic modulation impacts conduction velocity dynamics and wavefront propagation in the left atrium.

ABSTRACT:

Aims

Atrial fibrosis and autonomic remodelling are proposed pathophysiological mechanisms in atrial fibrillation (AF). Their impact on conduction velocity (CV) dynamics and wavefront propagation was evaluated.

Methods and results

Local activation times (LATs), voltage, and geometry data were obtained from patients undergoing ablation for persistent AF. LATs were obtained at three pacing intervals (PIs) in sinus rhythm (SR). LATs were used to determine CV dynamics and their relationship to local voltage amplitude. The impact of autonomic modulation- pharmacologically and with ganglionated plexi (GP) stimulation, on CV dynamics, wavefront propagation, and pivot points (change in wavefront propagation of ≥90°) was determined in SR. Fifty-four patients were included. Voltage imp

SUBMITTER: Honarbakhsh S 

PROVIDER: S-EPMC11372476 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature