Universal Genetic Testing for Newly Diagnosed Invasive Breast Cancer.

ABSTRACT:

Importance

Between 5% and 10% of breast cancer cases are associated with an inherited germline pathogenic or likely pathogenic variant (GPV) in a breast cancer susceptibility gene (BCSG), which could alter local and systemic therapy recommendations. Traditional genetic testing criteria misses a proportion of these cases.

Objective

To evaluate the prevalence and clinicopathological associations of GPVs in 2 groups of BCSGs among an ethnically diverse cohort of women with newly diagnosed breast cancer.

Design, setting, and participants

This cross-sectional study, conducted at 3 Montreal hospitals between September 2019 and April 2022, offered universal genetic counseling and testing to all women with a first diagnosis of invasive breast cancer. Women were offered an obl

SUBMITTER: Rezoug Z 

PROVIDER: S-EPMC11372499 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature