Bidirectional association identified between synovitis and knee and hand osteoarthritis: a general population-based study.

ABSTRACT:

Background

Synovitis has long been considered a common and modifiable inflammatory feature of osteoarthritis (OA), but current disease-modifying anti-inflammatory treatments appear ineffective in OA clinical trials. Elucidating the temporal relationship between synovitis and OA could provide insight into the role of synovitis in OA.

Methods

We conducted a prospective cohort study based on the baseline and three-year follow-up data from the Xiangya Osteoarthritis (XO) Study. We assessed bidirectional associations between ultrasound-detected synovitis and radiographic and symptomatic OA at knee and hand sites using generalized estimating equations. Additionally, we performed bidirectional Mendelian randomization (MR) analyses to test these hypotheses utilising whole-genome seq

SUBMITTER: Jiang T 

PROVIDER: S-EPMC11372600 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature