Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization.

ABSTRACT:

Background

Predictive performance of polygenic risk scores (PRS) varies across populations. To facilitate equitable clinical use, we developed PRS for coronary heart disease (CHD; PRS_CHD) for 5 genetic ancestry groups.

Methods

We derived ancestry-specific and multi-ancestry PRS_CHD based on pruning and thresholding (PRS_PT) and ancestry-based continuous shrinkage priors (PRS_CSx) applied to summary statistics from the largest multi-ancestry genome-wide association study meta-analysis for CHD to date, including 1.1 million participants from 5 major genetic ancestry groups. Following training and optimization in the Million Veteran Program, we evaluated the best-performing PRS_CHD in 176,988 individuals across 9 diverse cohort

SUBMITTER: Smith JL 

PROVIDER: S-EPMC11372723 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature