Treatment interruption and discontinuation of hormonal therapy in hormone receptor-positive breast cancer patients.

ABSTRACT:

Purpose

To investigate predictors of treatment interruption and early discontinuation of adjuvant hormonal therapy (HT) in a retrospective cohort of women with newly diagnosed hormone receptor-positive (HR +) breast cancer.

Methods

Eligible cases were identified from a single institutional tumor registry from 2009 to 2015. Patients were followed from initiation of adjuvant HT for a minimum of one year through December 1, 2016. Predictors of treatment interruption or early discontinuation were analyzed with Cox proportional hazards regression models.

Results

With a median follow-up time of 3.0 years (IQR 1.5-4.5), 22 women (10.9%) discontinued HT early and 47 (23.4%) had at least one treatment interruption of > 14 days. Adjusted Cox proportional hazards regression mode

SUBMITTER: Mao D 

PROVIDER: S-EPMC11372730 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature