Self-Chemiluminescence-Triggered Ir(III) Complex Photosensitizer for Photodynamic Therapy against Hypoxic Tumor.

ABSTRACT: The limited optical penetration depth and hypoxic tumor microenvironment (TME) are key factors that hinder the practical applications of conventional photodynamic therapy (PDT). To fundamentally address these issues, self-luminescent photosensitizers (PSs) can achieve efficient PDT. Herein, a self-chemiluminescence (CL)-triggered Ir complex PS, namely, IrL2, with low-O₂-dependence type I photochemical processes is reported for efficient PDT. The rational design achieves efficient chemiluminescence resonance energy transfer (CRET) from covalently bonded luminol units to the Ir complex in IrL2 under the catalysis of H₂O₂ and hemoglobin (Hb) to generate O₂^•- and ¹O₂. Liposome IrL2H nanoparticles

SUBMITTER: Liu S 

PROVIDER: S-EPMC11372751 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature