Metal free C-O bond cleavage: a new strategy for the synthesis of substituted oxazoles.

ABSTRACT: A strategy for the efficient metal-free C-O bond cleavage of ester using amines for the synthesis of substituted oxazoles was developed for the first time. The synthesis proceeded smoothly under metal-free conditions, combining C-O bond cleavage as well as C-N and C-O bond formation in one pot to yield desired products in moderate to excellent yields, and accommodated a wide range of functional groups and substrates.

SUBMITTER: Li S 

PROVIDER: S-EPMC11372780 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature