Evaluation of the COVID-19 vaccine effectiveness on the outcomes of COVID 19 disease in Iran: a test-negative case-control study.

ABSTRACT:

Introduction

This study measures the COVID-19 vaccine effectiveness (CVE) against hospital admission and severe COVID-19.

Methods

This study is a test-negative case-control design using data from eight provinces in April, 2021 until March, 2022. The individuals were classified as cases and controls based on the results of the RT-PCR test for SARS-CoV-2 and matched based on the timing of the test being conducted as well as the timing of hospital admission. The measure of association was an odds ratio (OR) by univariate and multiple logistic regression. The multiple logistic regression has been carried out to take confounding factors and potential effect modifiers into account. The CVE was computed as CVE = (1 - OR)*100 with 95% confidence interval.

Results

Among 19314

SUBMITTER: Khosravi Shadmani F 

PROVIDER: S-EPMC11372784 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature