Effect of benralizumab on inflammation in skin after intradermal allergen challenge in patients with moderate-to-severe atopic dermatitis.

ABSTRACT:

Background

Atopic dermatitis (AD) is a skin barrier dysfunction characterized by tissue eosinophilia.

Objective

In patients with AD, we evaluated the effect of eosinophil depletion with benralizumab on markers of inflammation in skin after intradermal allergen challenge.

Methods

A total of 20 patients with moderate-to-severe AD completed a randomized, double-blind, placebo-controlled parallel-group study comparing 3 doses of benralizumab (30 mg each) administered subcutaneously every 4 weeks (n = 9) with placebo (n = 11). Allergen and saline control intradermal challenges were conducted before and after treatment, with skin biopsy samples collected 24 hours after challenge. Early and late cutaneous responses were measured by skin wheal size. Levels of eosinophils and

SUBMITTER: Whetstone CE 

PROVIDER: S-EPMC11372810 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature