Unraveling the Potential of Vitamin B₃-Derived Salts with a Salicylate Anion as Dermal Active Agents for Acne Treatment.

ABSTRACT: This study is focused on the utilization of naturally occurring salicylic acid and nicotinamide (vitamin B₃) in the development of novel sustainable Active Pharmaceutical Ingredients (APIs) with significant potential for treating acne vulgaris. The study highlights how the chemical structure of the cation significantly influences surface activity, lipophilicity, and solubility in aqueous media. Furthermore, the new ionic forms of APIs, the synthesis of which was assessed with Green Chemistry metrics, exhibited very good antibacterial properties against common pathogens that contribute to the development of acne, resulting in remarkable enhancement of biological activity ranging from 200 to as much as 2000 times when compared to salicylic acid alone. The molecular docking

SUBMITTER: Olejniczak A 

PROVIDER: S-EPMC11372839 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature