Intrinsically disordered sequences can tune fungal growth and the cell cycle for specific temperatures.

ABSTRACT: Temperature can impact every reaction essential to a cell. For organisms that cannot regulate their own temperature, adapting to temperatures that fluctuate unpredictably and on variable timescales is a major challenge. Extremes in the magnitude and frequency of temperature changes are increasing across the planet, raising questions as to how the biosphere will respond. To examine mechanisms of adaptation to temperature, we collected wild isolates from different climates of the fungus Ashbya gossypii, which has a compact genome of only ∼4,600 genes. We found control of the nuclear division cycle and polarized morphogenesis, both critical processes for fungal growth, were temperature sensitive and varied among the isolates. The phenotypes were associated with naturally varying sequences wit

SUBMITTER: Stormo BM 

PROVIDER: S-EPMC11372857 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature