Lithium-induced apoptotic cell death is not accompanied by a noticeable inflammatory response in the kidney.

ABSTRACT: Lithium (Li⁺) therapy is a valuable tool in psychiatric practice that remains underutilized due to safety concerns. Excessive plasma Li⁺ levels are nephrotoxic and can trigger a local immune response. Our understanding of the immunomodulatory effects of Li⁺ in the kidney is fragmentary. Here, we studied how immune mechanisms contribute to the development of Li⁺-induced adverse effects in the kidneys of C57BL/6NJ mice placed on a 0.3% lithium carbonate diet for 28 days. We combined histochemical techniques, immunoblotting, flow cytometry, qPCR and proteome profiler arrays to characterize renal tissue damage, infiltrating immune cells and cytokine markers, activation of pyroptotic and apoptotic cascades in the kidneys of mice receiving Li⁺

SUBMITTER: Baranovskaya I 

PROVIDER: S-EPMC11373137 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature