Fenofibrate to prevent amputation and reduce vascular complications in patients with diabetes: FENO-PREVENT.

ABSTRACT:

Background

The potential preventive effect of fenofibrate on lower extremity amputation (LEA) and peripheral arterial disease (PAD) in patients with type 2 diabetes (T2D) is not fully elucidated.

Methods

We selected adult patients ≥ 20 years of age with T2D from the Korean National Health Insurance Service Database (2009-2012). The fenofibrate users were matched in a 1:4 ratio with non-users using propensity scores (PS). The outcome variables were a composite of LEA and PAD and the individual components. The risks of outcomes were implemented as hazard ratio (HR) with 95% confidence intervals (CI). For safety issues, the risks of acute kidney injury, rhabdomyolysis and resulting hospitalization were analyzed.

Results

A total of 114,920 patients was included in the ana

SUBMITTER: Ku EJ 

PROVIDER: S-EPMC11373174 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature