Divergent effects of tumor necrosis factor (TNF) in sepsis: a meta-analysis of experimental studies.

ABSTRACT:

Introduction

Experimental studies in animals have yielded conflicting results on the role of Tumor Necrosis Factor (TNF) in sepsis and endotoxemia, with some reporting adaptive and others inappropriate effects. A meta-analysis of the available literature was performed to determine the factors explaining this discrepancy.

Methods

The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The protocol was registered with PROSPERO (CRD42020167384) prior to data collection. PubMed and Embase were the databases queried. Risk of bias was evaluated using the SYRCLE Risk of Bias Tool. All animal studies investigating sepsis-related mortality and modified TNF signaling were considered eligible. The exclusion criteria were: lack of mo

SUBMITTER: Kassasseya C 

PROVIDER: S-EPMC11373197 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature