In vitro efficacy of next-generation dihydrotriazines and biguanides against babesiosis and malaria parasites.

ABSTRACT: Babesia and Plasmodium pathogens, the causative agents of babesiosis and malaria, are vector-borne intraerythrocytic protozoan parasites, posing significant threats to both human and animal health. The widespread resistance exhibited by these pathogens to various classes of antiparasitic drugs underscores the need for the development of novel and more effective therapeutic strategies. Antifolates have long been recognized as attractive antiparasitic drugs as they target the folate pathway, which is essential for the biosynthesis of purines and pyrimidines, and thus is vital for the survival and proliferation of protozoan parasites. More efficacious and safer analogs within this class are needed to overcome challenges due to resistance to commonly used antifolates, such as pyr

SUBMITTER: Vydyam P 

PROVIDER: S-EPMC11373198 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature