Plasmid-mediated acquisition and chromosomal integration of <i>bla</i>_CTX-M-14 in a subclade of <i>Escherichia coli</i> ST131-<i>H</i>30 clade C1.

ABSTRACT: Escherichia coli ST131 is a multidrug-resistant lineage associated with the global spread of extended-spectrum β-lactamase-producing organisms. Particularly, ST131 clade C1 is the most predominant clade in Japan, harboring bla_CTX-M-14 at a high frequency. However, the process of resistance gene acquisition and spread remains unclear. Here, we performed whole-genome sequencing of 19 E. coli strains belonging to 12 STs and 12 fimH types collected between 1997 and 2016. Additionally, we analyzed the full-length genome sequences of 96 ST131-H30 clade C0 and C1 strains, including those obtained from this study and those registered in public databases, to understand how ST131 clade C1 acquired and spread bla_CTX-M-14. We detected con

SUBMITTER: Komori K 

PROVIDER: S-EPMC11373201 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature