Exploring serine-arginine rich splicing factors: potential predictive markers for dysregulation in oral cancer.

ABSTRACT:

Background

Dysregulated splicing events are a common phenomenon in cancer with the Serine-arginine-rich splicing factor (SRSF) family emerging as pivotal regulators of gene expression, exerting influence over constitutive and alternative splicing processes. Although aberrations in a few SRSF family members have been implicated in various cancers, the comprehensive roles of other family constituents remain underexplored.

Methods

This study delves into the expression profile of the entire SRSF family (SRSF1-SRSF12) in 23 cancerous cell lines originating from diverse tissues using quantitative Real-Time PCR. Further, the transcript levels of the SRSF family were examined in oral cancer patient samples stratified into Pre-cancer (n = 15), Early cancer (n = 11), Late cancer (n = 

SUBMITTER: Sharma S 

PROVIDER: S-EPMC11373262 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature