The association of psychological and trauma-related factors with biological and facial aging acceleration: evidence from the UK Biobank.

ABSTRACT:

Background

Psychological and trauma-related factors are associated with many diseases and mortality. However, a comprehensive assessment of the association between psycho-trauma exposures and aging acceleration is currently lacking.

Methods

Using data from 332,359 UK Biobank participants, we calculated biological aging acceleration, indexed by the presence of leukocyte telomere length (LTL) deviation (i.e., the difference between genetically determined and observed LTL > 0). The acceleration of facial aging (i.e., looking older than the chronological age) was assessed using a self-report question. Then, we estimated the associations of each psycho-trauma factor with biological and facial aging acceleration, using logistic regression models adjusted for multiple important cov

SUBMITTER: Wang J 

PROVIDER: S-EPMC11373276 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature