Blunted tachycardia and cardiac sympathetic denervation in isolated rapid eye movement sleep behavior disorder.

ABSTRACT:

Background

Isolated rapid eye movement sleep behavior disorder (iRBD) serves as a prodromal phase of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Blunted tachycardia (BT) during postural changes indicates neurogenic orthostatic hypotension, a marker of autonomic dysfunction. We aimed to investigate whether BT is associated with cardiac sympathetic neurogenic denervation. Additionally, we conducted a preliminary short-term follow-up to examine the potential prognostic significance of BT regarding phenoconversion and mortality.

Methods

Forty-three patients with iRBD at Shiga University of Medical Science Hospital underwent active standing tests to identify BT, defined by a specific ratio of decrease in systolic blood pressure to inadequate increase in heart ra

SUBMITTER: Saeda S 

PROVIDER: S-EPMC11373284 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature