Case reports of persistent SARS-CoV-2 infection outline within-host viral evolution in immunocompromised patients.

ABSTRACT:

Background

SARS-CoV-2 is responsible for the ongoing global pandemic, and the continuous emergence of novel variants threatens fragile populations, such as immunocompromised patients. This subgroup of patients seems to be seriously affected by intrahost viral changes, as the pathogens, which are keen to cause replication inefficiency, affect the impaired immune system, preventing efficient clearance of the virus. Therefore, these patients may represent an optimal reservoir for the development of new circulating SARS-CoV-2 variants. The following study aimed to investigate genomic changes in SARS-CoV-2-positive immunocompromised patients over time.

Methods

SARS-CoV-2-positive nasopharyngeal swabs were collected at different time points for each patient (patient A and patient

SUBMITTER: Ruotolo L 

PROVIDER: S-EPMC11373299 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature