Endometriotic tissue fragments are viable after cryopreservation in an ex vivo tissue model recapitulating the fibrotic microenvironment.

ABSTRACT:

Study question

Is it possible to establish an ex vivo endometriosis model using cryopreserved endometriotic tissue fragments?

Summary answer

Cryopreserved endometriotic tissue fragments remain viable after thawing and during at least 3 days of culture and can therefore be used to establish an ex vivo endometriosis model to efficiently test potential therapeutic agents.

What is known already

Endometriosis is the most prevalent benign gynecologic disease with an enormous societal burden; however, curative therapies are still lacking. To efficiently test potential new therapies, an ex vivo model based on previously cryopreserved endometriotic tissue that recapitulates the different endometriosis subtypes and their microenvironment is highly desirable.

Study design, si

SUBMITTER: Vissers G 

PROVIDER: S-EPMC11373316 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature