Longitudinal associations between urinary biomarkers of phthalates and replacements with novel in vivo measures of placental health.

ABSTRACT:

Study question

What is the longitudinal association between gestational phthalate exposure and in vivo placental outcomes?

Summary answer

Phthalates were adversely associated with placental microvasculature, stiffness, and presence of calcification, with different metabolites associated with different outcomes.

What is known already

Phthalate exposure is ubiquitous and implicated as a contributor to adverse pregnancy outcomes, possibly through impacts on the placenta.

Study design, size, duration

A total of 303 women were recruited in early pregnancy and prospectively followed for up to eight visits across gestation in the Human Placenta and Phthalates study.

Participants/materials, setting, methods

At each visit, women provided urine samples and underwe

SUBMITTER: Rosen EM 

PROVIDER: S-EPMC11373341 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature