Granulosa cell metabolism at ovulation correlates with oocyte competence and is disrupted by obesity and aging.

ABSTRACT:

Study question

Is oocyte developmental competence associated with changes in granulosa cell (GC) metabolism?

Summary answer

GC metabolism is regulated by the LH surge, altered by obesity and reproductive aging, and, in women, specific metabolic profiles are associated with failed fertilization versus increased blastocyst development.

What is known already

The cellular environment in which an oocyte matures is critical to its future developmental competence. Metabolism is emerging as a potentially important factor; however, relative energy production profiles between GCs and cumulus cells and their use of differential substrates under normal in vivo ovulatory conditions are not well understood.

Study design, size, duration

This study identified metabolic and sub

SUBMITTER: Morimoto A 

PROVIDER: S-EPMC11373349 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature