Identification and functional analysis of C-type lectin from mosquito Aedes albopictus in response to dengue virus infection.

ABSTRACT:

Background

C-type lectins (CTLs) are a large family of proteins with sugar-binding activity. CTLs contain an evolutionarily conserved C-type lectin domain (CTLD) that binds microbial carbohydrates in a calcium-dependent manner, thereby playing a key role in both microbial pathogenesis and innate immune responses. Aedes albopictus is an important vector for transmitting dengue virus (DENV) worldwide. Currently, the molecular characteristics and functions of CTLs in Ae. albopictus are largely unknown.

Methods

Transcripts encoding CTL proteins in the Ae. albopictus genome assembly were analyzed via sequence blast. Phylogenetic analysis and molecular characterization were performed to identify the functional domains of the CTLs. Quantitative analysis was performed to determine t

SUBMITTER: Gao S 

PROVIDER: S-EPMC11373435 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature