Long-term persistence of diverse clones shapes the transmission landscape of invasive Listeria monocytogenes.

ABSTRACT:

Background

The foodborne bacterium Listeria monocytogenes (Lm) causes a range of diseases, from mild gastroenteritis to invasive infections that have high fatality rate in vulnerable individuals. Understanding the population genomic structure of invasive Lm is critical to informing public health interventions and infection control policies that will be most effective especially in local and regional communities.

Methods

We sequenced the whole draft genomes of 936 Lm isolates from human clinical samples obtained in a two-decade active surveillance program across 58 counties in New York State, USA. Samples came mostly from blood and cerebrospinal fluid. We characterized the phylogenetic relationships, population structure, antimicrobial resistance genes, virulence genes, and m

SUBMITTER: Ikhimiukor OO 

PROVIDER: S-EPMC11373459 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature