Development and characterization of a novel poly(<i>N</i>-isopropylacrylamide)-based thermoresponsive photoink and its applications in DLP bioprinting.

ABSTRACT: The field of 3-dimensional (3D) bioprinting has significantly expanded capabilities in producing precision-engineered hydrogel constructs, and recent years have seen the development of various stimuli-responsive bio- and photoinks. There is, however, a distinct lack of digital light processing (DLP)-compatible photoinks with thermoresponsivity. To remedy this, this work focuses on formulating and optimizing a versatile ink for DLP printing of thermoresponsive hydrogels, with numerous potential applications in tissue engineering, drug delivery, and adjacent biomedical fields. Photoink optimization was carried out using a multifactorial study design. The optimized photoink yielded crosslinked hydrogels with strong variations in hydrophobicity (contact angles of 44.4° LCST), ind

SUBMITTER: Perera KDC 

PROVIDER: S-EPMC11373533 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature