Integration of proteomics and transcriptomics to construct a prognostic signature of renal clear cell carcinoma.

ABSTRACT: Background: Protein information is often replaced by RNA data in studies to understand cancer-related biological processes or molecular functions, and proteins of prognostic significance in Kidney clear cell carcinoma (KIRC) remain to be mined. Methods: The cancer genome atlas program (TCGA) data was utilized to screen for proteins that are prognostically significant in KIRC. Machine learning algorithms were employed to develop protein prognostic models. Additionally, immune infiltration abundance, somatic mutation differences, and immunotherapeutic responses were analyzed in various protein risk subgroups. Ultimately, the validation of protein-coding genes was confirmed by utilizing an online database and implementing quantitative real-time PCR (qRT-PCR). Results: The patients were divide

SUBMITTER: Cheng G 

PROVIDER: S-EPMC11373548 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature