Commensal bacteria exacerbate seizure-like phenotypes in Drosophila voltage-gated sodium channel mutants.

ABSTRACT: Mutations in voltage-gated sodium (Na_v) channels, which are essential for generating and propagating action potentials, can lead to serious neurological disorders, such as epilepsy. However, disease-causing Na_v channel mutations do not always result in severe symptoms, suggesting that the disease conditions are significantly affected by other genetic factors and various environmental exposures, collectively known as the "exposome". Notably, recent research emphasizes the pivotal role of commensal bacteria in neural development and function. Although these bacteria typically benefit the nervous system under normal conditions, their impact during pathological states remains largely unknown. Here, we investigated the influence of commensal microbes on seizure-like phenot

SUBMITTER: Lansdon P 

PROVIDER: S-EPMC11373613 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature