<i>DAB2</i> ⁺ macrophages support <i>FAP</i> ⁺ fibroblasts in shaping tumor barrier and inducing poor clinical outcomes in liver cancer.

ABSTRACT: Background: Cancer-associated fibroblasts (CAFs) are the key components of the immune barrier in liver cancer. Therefore, gaining a deeper understanding of the heterogeneity and intercellular communication of CAFs holds utmost importance in boosting immunotherapy effectiveness and improving clinical outcomes. Methods: A comprehensive analysis by combing single-cell, bulk, and spatial transcriptome profiling with multiplexed immunofluorescence was conducted to unravel the complexities of CAFs in liver cancer. Results: Through an integrated approach involving 235 liver cancer scRNA-seq samples encompassing over 1.2 million cells, we found that CAFs were particularly increased in hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). FAP ^+</

SUBMITTER: Long F 

PROVIDER: S-EPMC11373629 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature