A relay-type innate immunity activation strategy involving water-soluble NIR-II AIEgen for boosted tumor photo-immunotherapy.

ABSTRACT: Background: Effective innate immunity activation could dramatically improve the anti-tumor efficacy and increase the beneficiary population of immunotherapy. However, the anti-tumor effect of unimodal immunotherapy is still not satisfactory. Methods: Herein, a novel relay-type innate immunity activation strategy based on photo-immunotherapy mediated by a water-soluble aggregation-induced emission luminogen, PEG₄₂₀-TQ, with the assistant of toll-like receptor 7 (TLR-7) agonist, imiquimod (R837), was developed and constructed. Results: The strategy could promote tumor cells to undergo immunogenic cell death (ICD) induced by the well-designed PEG₄₂₀-TQ@R837 (PTQ@R) nanoplatform under light irradiation, which in turn enhanced the infiltration of immun

SUBMITTER: Liu S 

PROVIDER: S-EPMC11373630 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature