Placental corticotrophin-releasing hormone trajectories in pregnancy: Associations with postpartum depressive symptoms.

ABSTRACT:

Objective

Depressive symptoms following birth are common and can have adverse effects for mothers, children, and families. Changes in hypothalamic-pituitary-adrenal (HPA) axis regulation during pregnancy may be implicated in the development of postpartum depressive symptoms, particularly changes in placental corticotropinreleasing hormone (pCRH). However, few studies have tested how dynamic pCRH changes over pregnancy relate to postpartum depressive symptoms. This preregistered investigation tests associations of both pCRH levels and changes from early to late pregnancy with postpartum depressive symptoms.

Methods

The sample consists of 173 women studied in early, mid, and late pregnancy who later reported on depressive symptoms with the Edinburgh Postpartum Depression Scale

SUBMITTER: Almeida IF 

PROVIDER: S-EPMC11373738 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature