A biophysical minimal model to investigate age-related changes in CA1 pyramidal cell electrical activity.

ABSTRACT: Aging is a physiological process that is still poorly understood, especially with respect to effects on the brain. There are open questions about aging that are difficult to answer with an experimental approach. Underlying challenges include the difficulty of recording in vivo single cell and network activity simultaneously with submillisecond resolution, and brain compensatory mechanisms triggered by genetic, pharmacologic, or behavioral manipulations. Mathematical modeling can help address some of these questions by allowing us to fix parameters that cannot be controlled experimentally and investigate neural activity under different conditions. We present a biophysical minimal model of CA1 pyramidal cells (PCs) based on general expressions for transmembrane ion transport derived from the

SUBMITTER: McKiernan EC 

PROVIDER: S-EPMC11373847 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature