Neuroimaging of the effects of drug exposure or self-administration in rodents: A systematic review.

ABSTRACT: A systematic review of functional neuroimaging studies on drug (self-) administration in rodents is lacking. Here, we summarized effects of acute or chronic drug administration of various classes of drugs on brain function and determined consistency with human literature. We performed a systematic literature search and identified 125 studies on in vivo rodent resting-state functional magnetic resonance imaging (n = 84) or positron emission tomography (n = 41) spanning depressants (n = 27), opioids (n = 23), stimulants (n = 72), and cannabis (n = 3). Results primarily showed alterations in the striatum, consistent with the human literature. The anterior cingulate cortex and (nonspecific) prefrontal cortex were also frequently implicated. Upregulation was most often found after shorter admin

SUBMITTER: Drossel G 

PROVIDER: S-EPMC11374361 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature