Whole-brain intrinsic functional connectivity predicts symptoms and functioning in early psychosis.

ABSTRACT: Theories of psychotic illness suggest that abnormal intrinsic functional connectivity may explain its characteristic positive and disorganization symptoms as well as lead to impaired general functioning. Here we used resting state functional magnetic resonance imaging (fMRI) to evaluate associations between these symptoms and the degree to which global connectivity is abnormal in early psychosis (EP). Eighty-six healthy controls (HCs) and 108 individuals with EP with resting state fMRI data were included in primary analyses. The EP group included 83 participants with schizophrenia-spectrum disorders and 25 with bipolar disorder type I with psychotic features. A global intrinsic connectivity "similarity index" for each EP individual was determined by calculating its correlation with the ave

SUBMITTER: Smucny J 

PROVIDER: S-EPMC11374471 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature