Age-related differences in resting-state, task-related, and structural brain connectivity: graph theoretical analyses and visual search performance.

ABSTRACT: Previous magnetic resonance imaging (MRI) research suggests that aging is associated with a decrease in the functional interconnections within and between groups of locally organized brain regions (modules). Further, this age-related decrease in the segregation of modules appears to be more pronounced for a task, relative to a resting state, reflecting the integration of functional modules and attentional allocation necessary to support task performance. Here, using graph-theoretical analyses, we investigated age-related differences in a whole-brain measure of module connectivity, system segregation, for 68 healthy, community-dwelling individuals 18-78 years of age. We obtained resting-state, task-related (visual search), and structural (diffusion-weighted) MRI data. Using a parcellation o

SUBMITTER: Madden DJ 

PROVIDER: S-EPMC11374505 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature