Association between 35 blood and urine biomarkers and oral leukoplakia: a two-sample Mendelian randomization study.

ABSTRACT: Several existing studies have shown a correlation between some of the blood and urine biomarkers and oral leukoplakia (OLK). However, the causality of this relationship remains uncertain. Thus, this study aimed to examine the causal association between 35 blood and urine biomarkers and OLK. Single nucleotide polymorphisms (SNPs) associated with 35 blood and urine biomarkers were selected as instrumental variables (IVs) using a two-sample Mendelian randomization(MR) study to assess the causal relationship between the biomarkers and the risk of oral leukoplakia. We used the inverse variance weighted (IVW) method as the main analysis. Furthermore, several sensitivity analyses were performed to assess heterogeneity, horizontal pleiotropy, and stability. Based on the selection criteria of the I

SUBMITTER: Ouyang YL 

PROVIDER: S-EPMC11374601 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature