The novel family of Warbicin^® compounds inhibits glucose uptake both in yeast and human cells and restrains cancer cell proliferation.

ABSTRACT: Many cancer cells share with yeast a preference for fermentation over respiration, which is associated with overactive glucose uptake and breakdown, a phenomenon called the Warburg effect in cancer cells. The yeast tps1Δ mutant shows even more pronounced hyperactive glucose uptake and phosphorylation causing glycolysis to stall at GAPDH, initiation of apoptosis through overactivation of Ras and absence of growth on glucose. The goal of the present work was to use the yeast tps1Δ strain to screen for novel compounds that would preferentially inhibit overactive glucose influx into glycolysis, while maintaining basal glucose catabolism. This is based on the assumption that the overactive glucose catabolism of the tps1Δ strain might have a similar molecular cause as the Wa

SUBMITTER: Vanthienen W 

PROVIDER: S-EPMC11374660 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature