Mechanisms that clear mutations drive field cancerization in mammary tissue.

ABSTRACT: Oncogenic mutations are abundant in the tissues of healthy individuals, but rarely form tumours^1-3. Yet, the underlying protection mechanisms are largely unknown. To resolve these mechanisms in mouse mammary tissue, we use lineage tracing to map the fate of wild-type and Brca1^-/-;Trp53^-/- cells, and find that both follow a similar pattern of loss and spread within ducts. Clonal analysis reveals that ducts consist of small repetitive units of self-renewing cells that give rise to short-lived descendants. This offers a first layer of protection as any descendants, including oncogenic mutant cells, are constantly lost, thereby limiting the spread of mutations to a single stem cell-descendant unit. Local tissue remodelling during consecutive oestrous cycles lea

SUBMITTER: Ciwinska M 

PROVIDER: S-EPMC11374684 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature