ALKBH5-mediated m⁶A demethylation ameliorates extracellular matrix deposition in cutaneous pathological fibrosis.

ABSTRACT:

Background

Elevated extracellular matrix (ECM) accumulation is a major contributing factor to the pathogenesis of fibrotic diseases. Recent studies have indicated that N6-methyladenosine (m⁶A) RNA modification plays a pivotal role in modulating RNA stability and contribute to the initiation of various pathological conditions. Howbeit, the precise mechanism by which m⁶A influences ECM deposition remains unclear.

Methods

In this study, we used hypertrophic scars (HTSs) as a paradigm to investigate ECM-related diseases. We focused on the role of ALKBH5-mediated m⁶A demethylation within the pathological progression of HTSs and examined its correlation with clinical stages. The effects of ALKBH5 ablation on ECM components were studied both in vivo

SUBMITTER: Xu R 

PROVIDER: S-EPMC11374695 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature